Altered expression of pedilanthus tithymaloidus lectin binding glycoprotein on erythrocytes in thyroid disorders, a preliminary report

Abstract

Measurable morphological changes in plasma and cell membrane glycoprotein are noted in various diseases. Lectin mediated agglutination of red blood cell can reveal such alteration. Present investigation was undertaken to assess the binding characteristics of P. tithymaloidus agglutinin on erythrocytes from thyroid disorders to find any alteration in membrane glycoproteins. In our study, hyperthyroidism has shown significantly increased hemagglutination titer (82.3 ± 52.9), where as decreased hemagglutination titer has been observed in hypothyroidism (34.1 ± 23.1). Observed finding substantiate that thyroid induced metabolic stress bring change in membrane glycoproteins which is reflected in the form of altered lectin binding activity on erythrocyte.