Effect of traditional biochemical markers on endothelial dysfunction in preeclampsia

Abstract

The present study was undertaken to investigate endothelial dysfunction as root cause in pathogenesis of preeclampsia, which has not yet been clearly understood. Elevated oxygen free radicals partially explain endothelial cell damage. Our aim is to measure NO, LPO and uric acid levels as endothelial dysfunction markers in preeclamptic women. Thirty preeclamptic women and thirty gestational age matched normal pregnant women were included in the study. Mild and severe preeclampsia cases were evaluated for serum MDA, NO and uric acid levels. Serum MDA and uric acid levels were significantly raised in women with mild and severe preeclampsia when compared with normal pregnancy. Progressive increase in MDA levels were statistically significant with increased severity of disease from mild to severe. Significant reduction in mean NO levels were observed in preeclampsia as compared to normal pregnant women. We conclude decreased concentration of NO observed that point towards endothelial dysfunction which may be due to oxidative stress reflection as of MDA & uric acid.