Proconvusant activity of hypericum perforatum l. extract powder and its interaction with phenytoin and clonazepam in wistar rats

Abstract

Hypericum perforatum L. study is an herbal antidepressant, which acts by convulsions. The present (HP) therefore aims at exploring the influence inhibiting non-selectively, theand its interactions with commonly used of HP on convulsions reuptake of neurotransmitters like norepinephrine (NE), gamma amino butyric acid (GABA), dopamine (DA), serotoninHP, anticonvulsants viz...phenytoin and clonazepam in Wistar rats. (5HT) and glutamate. Though its antidepressant and anxiolytic activities werewell phenytoin and clonazepam in their therapeutic equivalent doses are documented, on convulsions induced by maximum its effect on convulsions. evaluated there is a paucity of information about electroshock seizure The present study therefore aims atisoniazid (INH).For the interaction on (MES), pentylenetetrazol (PTZ) and exploring the influence of HP convulsions and coadministration with phenytoin in MES studies and with studies, HP was its interactions with commonly used anticonvulsants viz...phenytoin and clonazepam studies. HLE, number of seizures, duration clonazepam in PTZ and INH in Wistar rats. HP, phenytoin and clonazepam in of seizure and time for onsetdosesrecovery from seizures were monitored. by their therapeutic equivalent and were evaluated on convulsions induced maximum electroshock the rats in MES pentylenetetrazol (PTZ) and isoniazid HP failed to protect seizure (MES), studies and worsened the seizures (INH).For by PTZ as well studies, HPalso reversed the protective effects of in induced the interaction as INH. It was coadministration with phenytoin MES studies in MES and of clonazepam in PTZ as INH studies. HLE, number phenytoin and with clonazepam in PTZ as well and INH seizure models. of The findings of the present study suggest for onset as well proconvulsant seizures, duration of seizure and time that HP possesses as recovery from seizures were might compromise the to protect the rats in MES studies and activity and monitored. HP failed efficacy of anticonvulsant therapy, if worsened the of the present study could be extrapolated to humans.reversed the the findings seizures induced by PTZ as well as INH. It also protective effects of phenytoin in MES and of clonazepam in PTZ and INH seizure models. The findings of the present study Pentylenetetrazole; Maximum Key words: Hypericum perforatum; Interaction; Isoniazid; suggest that HP possesses proconvulsant electroshock seizure.activity and might compromise the efficacy of anticonvulsant therapy, if the findings of the present study could be extrapolated to humans.