Abstract:
Objective: To investigate the effect of tinospora cordifolia (TC) on resutured incision and
dead space wounds in albino rats.
Materials and Methods: Resutured incision and dead space wounds were inflicted in
albino rats under light ether anesthesia with aseptic precautions. Treatment group received
tinospora cordifolia and control animals received vehicle orally for a period of 10 days. On
the 11th day, after estimating breaking strength of resutured incision wounds, animals were
sacrificed and granulation tissue removed from dead space wounds to estimate breaking
strength, hydroxyproline content, quantification of granulation tissue and histopathological
assessment in both control and treated groups.
Results: TC significantly (P<0.05) promoted the healing process in both the wound models
studied.
Conclusion: TC promote wound healing, perioperative use of TC could promote the
healing of surgical wounds.
