Abstract:
A review of all the adjuncts for intravenous regional anaesthesia
concluded that there is good evidence to recommend NonSteroidal Anti-Inflammatory agents
and pethidine in the dose of 30 mg dose as adjuncts to intravenous regional anaesthesia. But
there are no studies to compare pethidine of 30 mg dose to any of the NonSteroidal Anti-
Inflammatory agents.
Methods: In a prospective, randomized, double blind study, 45 patients were given intravenous
regional anaesthesia with either lignocaine alone or lignocaine with pethidine 30 mg or ligno-
caine with ketprofen 100 mg. Fentanyl was used as rescue analgesic during surgery. For the first
6 h of postoperative period analgesia was provided by fentanyl injection and between 6 and 24 h
analgesia was provided by diclofenac tablets. Visual analogue scores for pain and consumption
of fentanyl and diclofenac were compared.
Results: The block was inadequate for one case each in lignocaine group and pethidine group,
so general anaesthesia was provided. Time for the first dose of fentanyl required for post-
operative analgesia was significantly more in pethidine and ketoprofen groups compared to
lignocaine group (156.7 ± 148.8 and 153.0 ± 106.0 vs. 52.1 ± 52.4 min respectively). Total fen-
tanyl consumption in first 6 h of postoperative period was less in pethidine and ketoprofen groups
compared to lignocaine group (37.5 ± 29.0 mcg, 38.3 ± 20.8 mcg vs. 64.2 ± 27.2 mcg respec-
tively). Consumption of diclofenac tablets was 2.4 ± 0.7, 2.5 ± 0.5 and 2.0 ± 0.7 in the control,
pethidine and ketoprofen group respectively, which was statistically not significant. Side effects
were not significantly different between the groups.
