Abstract:
Guillain-Barre ́ syndrome (GBS) is an acute onset, immune-mediated polyneuropathy that often
follows an antecedent infection. The diagnosis is based on the clinical impression obtained from the history and
examination. Cerebrospinalfluid analysis and electro diagnostic testing usually provide evidence supportive of
the diagnosis.
Objectives: To study clinical presentation, treatment and outcome of patients with Guillain Barre Syndrome
(GBS).
Material and Methods: 20 patients of GBS studied in detail including history, clinical examination and
investigations. Those who developed respiratory insufficiency were given assisted mechanical ventilation.
Patients were treated with IVIG or plasmapheresis and outcome was observed.
Results: Commonest age group affected was 16-40 yrs. The male: female ratio was 1.2:1. Antecedent infection
was present in 6 out of 20 patients. 14 patients had quadriparesis and paraparesis in 6 patients. Cranial nerve
involvement was seen in 5 patients. Areflexia was found in all patients. NCV findings show conduction velocity
slowing, delayed f latencies in 90% patients. Out of 20 patients, 5 required mechanical ventilation. Out of 20
patients, 13 patients received only supportive treatment, 7 were treated with IVIg, 3 patientstreated with
plasmapheresis. Out of 20 patients, 16patients recovered completely, 2 patients expired and 2 patients developed
neurologic deficit.
Conclusion: GBS is more common in 16-40 yrs age group with male:female ratio of 1.2:1. Antecedent infection
is seen in 30% patients. Commonest presentation was ascending paralysis. 25%patients developed respiratory
paralysis and needed ventilatory support.
