Effect of topical tinospora cordifolia on excisional wound in albino rats

Abstract

Objective is to investigate the effect of topical tinospora cordifolia (TC) on excisional wound in albino rats. Excisional wounds were inflicted by excising the full thickness circular skin (approximately 500 mm2) from the nape of neck in albino rats under light ether anesthesia taking aseptic precautions. Treatment group received 1% tinospora cordifolia cream for 16 days from the day of wounding and the control group was left untreated. During the process of healing, wound-closure rate and epithelization time were assessed by tracing the wound on polythene paper from the day of wounding, followed by 4, 8, 12, 16th day and subsequently on alternate days till the complete epithelization. Similarly, scars were traced on complete epithelization to assess wound contraction by noting scar size and shape. The wound closure rate was expressed as percentage of the original wound size of 500 mm2 on selected days. Topical TC significantly (P<0.05) promoted the healing process in the excisional wound model studied. TC showed healing potential on excisional wound with the tested formulation and this property could possibly be used clinically in the healing of open wounds