Abstract:
Measurable morphological changes in plasma and cell membrane glycoprotein are
noted in various diseases. Lectin mediated agglutination of red blood cell can reveal such
alteration. Present investigation was undertaken to assess the binding characteristics of P.
tithymaloidus agglutinin on erythrocytes from thyroid disorders to find any alteration in
membrane glycoproteins. In our study, hyperthyroidism has shown significantly increased
hemagglutination titer (82.3 ± 52.9), where as decreased hemagglutination titer has been
observed in hypothyroidism (34.1 ± 23.1). Observed finding substantiate that thyroid
induced metabolic stress bring change in membrane glycoproteins which is reflected in the
form of altered lectin binding activity on erythrocyte.
