Abstract:
Imbalance in the oxidants and antioxidant status indicates on
going oxidative stress is considered as one of the etiological factor for development of
lung function abnormalities. However no study has been performed to assess the
oxidative stress in pulmonary tuberculosis. That’s why this study was over taken. Protein
Carbonyl (PC) and advanced oxidation protein product (AOPP) as protein oxidation
products (PPP) and antioxidants such as reduced glutathione (GSH),total thiol (TT)
levels were analyzed in 25 patients with diagnosed pulmonary tuberculosis (TB) and 25
normal healthy age and sex matched controls. Statistically significant increased (p-
0.001) levels of PC and AOPP were noted; GSH (p-0.013) and TT (p-0.001) levels
were decreased .Hence increased oxidative stress signified by increased protein
oxidation product and altered antioxidant levels may have a role in etiopathogenesis of
pulmonary tuberculosis.
