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Pattern of cutaneous adverse drug reactions due to the use of fixed dose drug combinations

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dc.contributor.author Sherkhane, Radhika M.
dc.contributor.author Sherkhane, Mayur S.
dc.contributor.author Kop, Priydarshini B.
dc.date.accessioned 2014-05-12T22:53:38Z
dc.date.available 2014-05-12T22:53:38Z
dc.date.issued 2013-09
dc.identifier.citation International Journal of Basic & Clinical Pharmacology. 2013 Sep-Oct; 2(5): 554-558 en_US
dc.identifier.issn 2319-2003, 2279-0780
dc.identifier.uri http://hdl.handle.net/123456789/546
dc.description.abstract Background: Fixed dose drug combinations (FDCs) possess a higher risk of causing adverse drug reactions (ADRs) compared to a drug used individually. This study analyzes the pattern of ADRs caused due to the use of FDCs in a tertiary care hospital. Methods: A prospective, spontaneous ADR reporting study was conducted for two years at a tertiary care hospital. ADRs reported due to suspected FDC use were evaluated for causality (WHO-UMC probability scale), severity (adapted Hartwig scale) and avoidability (Modified Hallas J. et al. scale). Results: Of the 29 (96.67%) cutaneous ADRs reported, 19 (63.34%) ADRs were due to irrational FDCs, of which 16 (53.34%) were ‘probable’, 13 (43.34%) were ‘possibly avoidable’ and 13 (43.34%) were ‘mild/level 2’ on the severity scale. Conclusion: Irrational FDCs carry a higher risk of causing cutaneous ADRs. Awareness and regular reporting of such ADRs can help physicians fight the evil of irrational prescribing. en_US
dc.language.iso en en_US
dc.publisher Medip Academy en_US
dc.subject Adverse drug reaction en_US
dc.subject Preventability en_US
dc.title Pattern of cutaneous adverse drug reactions due to the use of fixed dose drug combinations en_US
dc.type Article en_US


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