Effect of topical tinospora cordifolia on healing of burn wounds in wistar rats

Abstract

To investigate the effect of tinospora cordifolia (TC) on the healing of burn wounds in wistar rats and compare it with control and silver sulfadiazine treated groups. Materials and Methods: Partial thickness burn wounds were made on three groups of rats (n=6 in each group) at the nape of neck under ether anesthesia. The Burn wounds were treated topically with petroleum base, 1% silver sulfadiazine and 2% TC, respectively once daily till complete healing. The wound contraction rate and epithelialization time were observed. Data was analysed by one way ANOVA and Tukeys multiple post hoc procedures. Results: The mean epithelialization time was significantly (P<0.0004*) decreased in TC treated group compared to control and silver sulfadiazine groups. Percentage of wound contraction was significantly more on 4th (P<0.0003*), 8th (P<0.0019*), 12th (P<0.0060*) and 16th day (P<0.0016*) in TC treated group in comparison to the control. Conclusion: Topical TC showed healing potential on burn wounds in wistar rats